I doubt that neovagina is suitable for administration of progesterone. Contents of a capsule is absorbed through rectal wall, but the question is whether the capsule shell dissolves. Perhaps yes, but I'm not sure that in every patient. You mean because the internal wall of the neovagina is not a true mucosa? I assume that the only way to check if progesterone is fully absorbed would be that I go to the lab a few hours after capsule insertion.
I tried taking progesterone Prometrium capsules rectally in the past. I didn't notice any sedative mood altering effects nor did I notice any change in my skin or my breasts. On one occasion, I opened the capsule and inserted it rectally and became sleepy soon afterwards. Some transsexual women report an effect from taking the capsules this way but like Lena said, it might depend on the person. I also took suppositories, suitable for rectal administration, containing progesterone mg daily.
Absorption seemed poor and I noticed no significant including sedative effects. About 15 hours after insertion, levels were VERY low, at 7. If I ever go this route again, I would opt for mg twice daily. As always, level of metabolites that give sedative effects was very low when taken vaginally relative to oral. There is much variability across individuals too.
Suggesting overall but may depend on the individual that the rectal route is better if contents are accessible to wall. There is the risk and inconvenience of increased leakage and loss of contents from vagina, more than from rectum. Sublingual also, by the way, yields pretty good levels but results in greater fluctuations. I noticed absorption to be poorer when suppositories were in a base of "semi-synthetic glycerides produced from hydrogenated vegetable oil by interesterification" vs.
From this study, capsules taken vaginally and gel give poor numbers, whereas with suppositories, levels are significantly higher and probably depend on contents of suppository. Vaginal cream appears to be superior to gel. Also, regarding vaginal suppositories, "suppositories have been shown to produce high plasma levels of progesterone when first used but declining levels with continued adminstration.
Orally still remains, in my opinion, a good option, especially if you seek sedative effects. I have not yet read all 7 articles entirely but all of them seem very informative. The results observed for rectal absorption encourage me to go on with that route, at least for the morning intake.
At my next appointment with my endo I will ask her a prescription for lab testing of serum progesterone 2 hours after morning intake. If level is good I'll switch to rectal administration for both intakes. In any case, I thank you again Kristelle for providing all these useful references. I must add that progesterone suppositories are not available in my country, so I'll have to stick to capsules. Sublingual is probably more reliable but I cant stand the taste and its not convenient I rarely get drowsy from P but I do sometimes, I take mg 2 or three times a day, mg Usually the morning and afternoon dose is without food Im 4 months post op and Ive considered trying a mg capsule in my vagina before bed but I worry about the coating not dissolving in there and getting stuck up in there when I dilate in the morning Does anyone have dreams on progesterone??During these challenging times, we guarantee we will work tirelessly to support you.
We will continue to give you accurate and timely information throughout the crisis, and we will deliver on our mission — to help everyone in the world learn how to do anything — no matter what. Thank you to our community and to all of our readers who are working to aid others in this time of crisis, and to all of those who are making personal sacrifices for the good of their communities. We will get through this together. If your doctor has prescribed vaginal suppositories, you may be wondering how they work.
A suppository is a medicine delivery system that can be used to insert various drugs, herbs, hormones or lubricants into the vagina. Once the suppository is in your vagina, it will dissolve, releasing the medicine to treat a condition of the vagina like a yeast infection or the entire body like hormone treatments.
If you're inserting a tablet or ointment, the suppository might come with a plastic applicator to help you insert it. National Institutes of Health Go to source. If you need to insert a vaginal suppository, do it at night before bed since the suppository will leak as it dissolves. Before you insert the suppository, clean the outer parts of your vagina using a mild soap to prevent the spread of bacteria.
Then, stand with your legs and knees apart and raise one foot up on a stool or toilet. In this position, open the lips of your vulva and push the suppository into your vagina as far as you can. Push the plunger to release the suppository, then dispose of the applicator. For more tips, like how to store your suppositories until you need to use them again, read on. Did this summary help you?
TV A18 (Progesterone 100 mg)
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My progesterone dropped from Just wondering if anyone else has used the capsules vaginally.
Just looking for some friendly advice. Actually I just looked at mine and they do have that same writing on them so they are the same as yours and I take them vaginally. Like previous poster said, vaginally is supposed to be more effective. I hope everything works out for you, I know how worrisome this all is. Orally only increases your blood levels for progesterone, you need them near your uterus to do their work.
Top 10 Facts About Vaginal Progesterone and Assisted Reproductive Technologies
My RE says orally is a complete waste. Good luck! Yes, vaginally. Do not be scared when they dissolve. The applicators from preseed work well to get the capsule far up to your cervix. After 2 losses I took mg orally at bedtime 4 little white spheres mg each from the day i got my bfp until 13wk and now have a 4 year old. I just got bfp last week. I was also super drowsy the entire time but who knows if that was just pregnancy.
I did have a tiny spotting the first day but maybe it was just irritated or scratched? If you prefer to take orally talk to doc about taking a higher dose. Congrats to you! The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff.Drug information provided by: IBM Micromedex.
Vaginal estrogen products usually come with patient directions. Read them carefully before using this medicine. Wash your hands before and after using the medicine. Also, keep the medicine out of your eyes. If this medicine does get into your eyes, wash them out immediately, but carefully, with large amounts of tap water.
If your eyes still burn or are painful, check with your doctor. Use this medicine only as directed. Do not use more of it and do not use it for a longer time than your doctor ordered. It can take up to 4 months to see the full effect of the estrogens. Your doctor may reconsider continuing your estrogen treatment or may lower your dose several times within the first one or two months, and every 3 to 6 months after that. Sometimes a switch to oral estrogens may be required for added benefits or for higher doses.
When using the estradiol vaginal insert or ring, you will need to replace it every 3 months or remove it after 3 months. The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines.
If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
Do not double doses. When using the suppository or cream several times a week: If you miss a dose of this medicine and remember it within 1 or 2 days of the missed dose, use the missed dose as soon as possible. When using the cream or suppositories more than several times a week: If you miss a dose of this medicine, use it as soon as possible if remembered within 12 hours of the missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. All rights reserved.
This site complies with the HONcode standard for trustworthy health information: verify here. This content does not have an English version. This content does not have an Arabic version.My wife's doctor prescribed progesterone capsules for my wife to help her avoid a miscarriage, after we lost the last two babies within 2 months or less. He told her to insert the capsules in her vagina, whereas the info sheet only mentions oral, and from the internet we found that there are progesterone gels intended for vaginal insertion.
Question: is it ok effective and safe to follow the doctor's instructions to insert the capsules in my wife's vagina? My wife called the doctor back when she saw that the info sheet only mentioned oral use for the capsules, but the doctor insisted it was ok.
Thank you. Click here to add your own comments. Join in and write your own page! It's easy to do. Simply click here to return to Benefits of progesterone. See what's being discussed, ask for help, give your thoughts or experiences, or just browse See the FAQ pages. Visit the forums.IVF Progesterone Suppository Vaginally
I am Since the age of 47 in menopause. Since December I have had bloodwork done and it shows I am prediabetic. Hello, I am 40, after pregnancy 8 years ago I crashed and got so much fatigue that I could barely take care of myself an my baby. Since then I tried. Hello, I posted in previous posts I used mg of cream through my period this cycle and I had heavy bleeding and then it slowly stopped. On day 5 I. I am 53 years old and get my cycle every 28 days. I use about mg. Natural progesterone cream.
Discover the facts. Your language. Translate this website into your language. Is this the future of medicine? Watch this important video. Watch these videos. Subscribe to Progesterone News. Its free and will bring you important new information on progesterone therapy and related health matters.
This work is licensed under a Creative Commons Attribution 3. What is progesterone? Progesterone to avoid miscarriage - caps inserted vaginally by Tim Woodruff Bal Harbour FL usa My wife's doctor prescribed progesterone capsules for my wife to help her avoid a miscarriage, after we lost the last two babies within 2 months or less.Medically reviewed by Drugs. Last updated on Mar 7, This is not a list of all drugs or health problems that interact with progesterone vaginal insert. Tell your doctor and pharmacist about all of your drugs prescription or OTC, natural products, vitamins and health problems.
You must check to make sure that it is safe for you to take progesterone vaginal insert with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. Use progesterone vaginal insert as ordered by your doctor.
Read all information given to you. Follow all instructions closely. Progesterone dosage information in more detail. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:. All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:.
These are not all of the side effects that may occur.
Progesterone Vaginal Insert
If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects. You may report side effects to the FDA at Progesterone side effects in more detail. If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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Any suggestions on how to insert progesterone suppositories?
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Just so you know, What to Expect may make commissions on shopping links on this page. This discussion is archived and locked for posting. Archived discussions are usually a bit older and not as active as other community content. I start my progesterone vaginal suppositories compound tonight, no applicators!! Any suggestions for the best way to insert these?
Ashlove, Ash, when u say compound does that mean it's not a pill, but more of a cream? TBMinCanada, It's like a suppository you would use for constipation! It's white, and shaped like a bullet, I have insert 2 tonight! Ashlove, I used the same thing. I suppose that is really the only way to do it!